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And when that happens, a lot of people will see that initial weight loss in their face first." This rapid loss of facial fat can lead to sunken cheeks and temples, making the bones of the face appear more prominent. Additionally, the skin may lose elasticity and sag, accentuating existing wrinkles and fine lines

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Clinical trials leading to FDA approval demonstrated significant visceral fat reduction in patients with excess abdominal fat accumulation, validating what clinicians now see consistently in practice

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TRIUMPH-5 (head-to-head vs tirzepatide, NCT06662383) and TRIUMPH-Outcomes (CV/kidney CVOT, NCT06383390) are multi-year