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The decision should involve individualized risk-benefit assessment considering the specific autoimmune diagnosis, disease activity, and concurrent medications, with coordination between the prescribing clinician and the specialist managing the autoimmune condition
Prescribing restrictions are likely to relax over time, and coverage and penetration improve, as increased competition and the entry of generics drive price erosion
Abbreviations CD: Crohns disease DPP-IV: Dipeptidyl peptidase IV DSS: Dextran sulfate sodium EEC: Enteroendocrine cells GI: Gastrointestinal tract GIP: Gastro-insulinotropic peptide GLP: Glucagon-like peptide GM-CSF: Granulocyte-macrophage colony-stimulating factor IBD: Inflammatory bowel diseases IFN-: Interferon IGF-1: Insulin-like growth factor 1 IL: Interleukin LPS: Lipopolysaccharide PC 1/3: Prohormone convertase 1/3 PEG: Polyethylene glycosyl SCFA: Short-chain fatty acids TNBS: 2,4,6-trinitrobenzenesulfonic acid TNF-: Tumor necrosis factor UC: Ulcerative colitis References Abrahami D, Douros A, Yin H, et al (2018) Dipeptidyl peptidase-4 inhibitors and incidence of inflammatory bowel disease among patients with type 2 diabetes: population based cohort study
There have been reports of individuals receiving vials labeled as tirzepatide that contained semaglutide or other substances
Why did FDA end shortage-based compounding
Dunlay SM, Givertz MM, Aguilar D, Allen LA, Chan M, Desai AS, et al
