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In HNSCC, HGF is majorly secreted via tumor-associated fibroblasts (TAFs) in the tumor microenvironment [80, 81]
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Visible fat loss typically appears after 4 to 8 weeks of consistent use combined with proper diet and exercise
Within this framework, our observation of reduced thalamic GSH during the interictal phase may be regarded as a candidate neurochemical correlate of these chronic, between-attack thalamic changes, possibly reflecting cumulative oxidative burden in a region chronically exposed to trigeminovascular input over years of recurrent attacks
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