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Importantly, how viruses modulate the expression of Pelo-Hbs1 complex to promote sperm-mediated paternal transmission also remains unknown
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For instance, DHHC5- and DHHC2-mediated palmitoylation of nucleotide-binding oligomerization domain-containing protein 2 (NOD2) and B-raf proto-oncogene serine/threonine-protein kinase (B-RAF)/Raf-1 proto-oncogene serine/threonine-protein kinase (C-RAF), respectively, impedes their binding to the cargo receptors SQSTM1/p62 or optineurin (OPTN)/toll-interacting protein (TOLLIP) [140,141,142]
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Notably, the LASSS-pretreatment displayed greater preventive effect on nitration of Y198 compared to Y250, as revealed by re-probing with anti-nitroY198 and Y250-HGF mAbs (Figure 2b, first and second rows, lanes 2 and 3
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