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10.1152/physrev.00013.2014 Physiol Rev

Kidney failure (when your kidneys cannot do their normal functions)

FIGURE 1 Taken together, these scientific milestones and the rapid rise in scholarly output highlight the momentum of GLP-1based therapies

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Serious side effects include: Inflammation of the pancreas (pancreatitis) Diabetic eye disease (retinopathy) Severely low sugar levels if taken with insulin therapy Acute kidney injury Hypersensitivity Metformin is a relatively safe medication, but it can cause serious complications if there are underlying issues or if you aren't getting enough nutrients in your diet