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The methylcobalamin component is generally safe in renal impairment, though accumulation of cobalt has been reported in patients with severe renal dysfunction receiving high doses of vitamin B12

And its here where the concept of nasally administering BPC-157 attracted the attention of curious biohackers

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J.et al (2012)

Gallbladder considerations Rapid weight loss from any cause increases the risk of gallstone formation and gallbladder events