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Animal experiments Specific pathogen-free male C57BL/6 mice (SLAC Laboratory Animal Co., Ltd., Shanghai, China) were used

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Standard clinical thresholds commonly used in practice are BMI 30 kg/m or BMI 27 kg/m with obesity-related conditions such as type 2 diabetes, hypertension, or dyslipidemia

It was later found to be effective in aiding weight loss as well

For example, subcutaneous semaglutide for diabetes (Ozempic) typically starts at 0.25 mg weekly for four weeks before increasing to 0.5 mg, with further increases only if needed