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Fortunately, melanotic macules are harmless

Written informed consent from the participants legal guardian/next of kin was not required to participate in this study in accordance with the national legislation and the institutional requirements

They are chemically distinct: copper binding alters charge, conformation, and the chemistry researchers are usually probing, so the two are not interchangeable in experimental design

However, phenobarbital is effective and perhaps underutilized: Phenobarbital (15 mg/kg) was found to be equally effective as compared to lorazepam (0.1 mg/kg) as first-line therapy for status epilepticus in the VA-Cooperative trial

The 1-2% range hits that perfect balance for most skin types

Hellenic J Cardiol