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The authors concluded that both drugs have a small incidence of cardiac dysautonomia as an adverse event, the majority of which was classified as non-serious, but called for more studies

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GLP-1 agonists are thought to flip that switch back to the OFF or at minimum, act as a dimmer switch to tone down the intensity of the ON signaling thereby reducing the production of inflammatory cytokines

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Treatment typically begins with a low starter dose (0.25 mg weekly for 4 weeks), followed by gradual increases (0.5 mg, then up to 12 mg weekly for Ozempic, or up to 2.4 mg for Wegovy), depending on tolerability and clinical response

Slow Dose Escalation Jumping doses too quickly is a major driver of side effects