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They do not differ in the fundamental constraint: molecules above roughly 500 daltons don't cross intact stratum corneum passively, and the botanicals that do fit under that threshold arrive at doses two to three orders of magnitude below anything studied

Altern.Med Rev

Y., and Park, S

Given the complementary roles of PDE1B and PDE10A within striatal dopaminergic circuits, selective inhibition of either enzyme addresses only specific symptom domains of schizophrenia, limiting overall therapeutic efficacy

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