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A progressive gradient in GM changes was also observed between healthy, constipated, prodromal PD (characterised by constipation, hyposmia and probable RBD) and PD individuals, showing a gradual decrease in total abundance of strict anaerobes with anti-inflammatory properties (including Roseburia inulinivorans , Roseburia intestinalis and Faecalibacterium prausnitzii ) [128]
Additional investigations have explored relationships between GHK-Cu and copper-dependent regulatory proteins, redox-associated signaling pathways, and metalloprotein activity, contributing to a broader understanding of metallopeptide signaling systems
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10.1016/S1474-4422(14)70117-6 107 WilsonD
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