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In healthy, balanced skin, MMPs and their inhibitors (TIMPs) work in careful equilibrium
ER stress activation can mitigate protein synthesis, induce ER chaperones to facilitate protein folding, and increase ER-associated degradation to reduce protein load
Dor, et al
Scientists then traced the pathway responsible and found it was entirely separate from the tanning mechanism, rooted in melanocortin receptor activity in the hypothalamus (the brain region involved in regulating motivation and desire) rather than in the skin
pmid:2199596 12
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