The first GLP-1RA was discovered in the Gila monster, a desert-dwelling lizard capable of consuming up to half its body weight in a single meal while maintaining stable blood glucose levels
In the SURMOUNT-5 head-to-head trial ( N Engl J Med , May 2025), tirzepatide produced 20.2% average weight loss compared to 13.7% with semaglutide over 72 weeks a 47% greater relative reduction
Partially hydrolyzed guar gum in the treatment of irritable bowel syndrome with constipation: effects of gender, age, and body mass index
Most people focus on calories, cardio, and macros but overlook the fact that your gut bacteria directly influence how your body stores fat, handles glucose, and responds to insulin
It suggests that even well-designed compounds with plausible mechanisms and positive animal data may not translate to human benefit
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