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The medication is initiated at a low dose (0.25 mg) and gradually increased over 16 weeks to the maintenance dose of 2.4 mg to minimise gastrointestinal side effects, which are common during the early stages of treatment

Integration of enrichment analyses and volcano plots further confirmed metabolic reprogramming, with upregulation of OXPHOS (Hallmark OXPHOS), fatty acid metabolism (GOBP Fatty Acid Metabolic Process), and mitochondrial proteins (MitoCarta 3.0)

doi: 10.1016/j.ygcen.2017.12.007 154 ZengXXieYJLiuYTLongSLMoZC

Objective inflammation assessment: Depending on the clinical situation, assessment may include blood tests, stool markers such as faecal calprotectin, imaging, colonoscopy, gastroscopy or other investigations to understand whether symptoms are linked to active inflammation or another gut condition

This can work alongside GLP-1 medications to manage blood sugar levels and weight

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