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Most studies remain preclinical or experimental
It also reduces the chance of relying on self-treatment when formal testing is needed
Studies using techniques like microneedling show dramatically enhanced penetration - up to ten-fold increases - but even standard topical application delivers meaningful amounts to the target tissue
(PubMed) Kuiper C, Vissers MC, Hicks KO
Patients show symptoms well above this mark, as B12 depletion appears in the cerebrospinal fluid even when blood levels are as high as 550
Montelongo-Jauregui D, Saville SP, Lopez-Ribot JL
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