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Proposed Mechanisms (Preclinical) Incretin & Glucose Control Activates GLP-1 receptors on pancreatic -cells to enhance glucose-dependent insulin secretion
Senolytic drugs such as the BCL2 family inhibitors ABT-263 and ABT-737 23,24,34 selectively killed senescent IMR90 ER:RAS cells when compared with non-senescent controls (Extended Data Fig
(13) A key mechanism through which GLP-1 receptor agonists may influence bone metabolism is the osteoprotegerin (OPG)/RANKL/RANK pathway, which regulates osteoclast differentiation and bone resorption
61, 2002 [5] R
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