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A GLP-1 and GIP analogue should only be offered to adults with T2DM, in combination with insulin with specialist care advice and ongoing support from a consultant-led multidisciplinary team

A single-arm, open-label Phase 2 extension study (NCT01861249) evaluating the long-term safety and tolerability of SAR339658 over 62 weeks in patients with UC who had previously completed the initial 8-week treatment in the primary study (ACT12688) with acceptable safety profiles

Then theres tirzepatide, sold as Zepbound and Mounjaro, which mimics not only GLP-1 but also glucose-dependent insulinotropic polypeptide, or GIP

Reconstituted (with sterile water): Use immediately

While highly effective for managing type 2 diabetes and aiding in weight loss, the out-of-pocket costs for these medications can be steep

Several studies point to a protective role of GLP-1RAs on retinal pigment epithelium (RPE) cells, which form the blood-retinal barrier and are vulnerable to inflammation [83, 84]