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In human AML stem cells, BCAT1 is overexpressed, and the BCAA pathway is activated by the low levels of -KG, displaying a DNA hypermethylation phenotype similar to IDH mutant-positive cancers (Raffel et al., 2017)

The researchers found that this combination successfully mitigated neuroinflammation and oxidative stress, with 8 out of 12 patients in the initial cohort experiencing substantial cognitive recovery, regaining their memory and multi-tasking abilities

Any such combination remains within the framework of preclinical models

10.4049/jimmunol.169.12.6668 J

Both groups improved similar amounts on the Sociability and Sensory/Cognitive Awareness subscales

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