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Animal studies, particularly in rodents, have shown that high-dose GLP-1 exposure can lead to pancreatic ductal proliferation and, in some cases, inflammatory changes

If your body has an adequate amount of Glutathione levels, your body is able to remove heavy metals, as well as reduce the damage and stress that exposure to heavy metal causes our cells

Thus, substitution of (replacing rather than adding) an agent with cardiorenal benefit might be appropriate if people are at or near A1c target

doi: 10.1016/j.immuni.2023.07.011 146 MannE

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Nat Rev Bioeng