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The insulinotropic effect of GIP, together with GLP-1, accounts for more than 70% of postprandial insulin secretion (50)

doi: 10.1038/s41422-022-00718-7 12 YangWSStockwellBR

In fact, one of our listeners wrote in and asked us to do a deep dive on this buzzy supplement

The activation of HCA2 by -hydroxybutyrate in adipose tissue, therefore, serves as a negative feed-back loop on adipose tissue lipolysis by reducing the release of free fatty acids from adipocytes

The main findings deduced by the results in this study are as follow: (1) GLP-1 increases RSNA to regulate diuresis and natriuresis in an inhibitory manner, in which the afferent renal nerve activation is potentiated via elevated GLP-1R expression in the renal pelvis of rats with HF

So we really wanted to tackle: if obesity is a disease and we want to treat it as such, like we have other chronic diseases, tell me what the signs and symptoms are of that disease