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It also activates the FAK-paxillin signaling pathway in tendon fibroblasts, promoting cytoskeletal reorganization and directed cell migration both essential steps in connective tissue repair

This leads to the accumulation of misfolded or aggregated proteins, the activation of endoplasmic reticulum stress and unfolded protein response, and further aggravation of heat-induced cellular injury (Hetz et al., 2020

However, the hydrophobic pocket formed by the three aromatic residues has been suggested to shield the catalytic nucleophile from bulk solvent and activating hydrolysis

Learn about hesperidin, including whether its beneficial for heart health, problems with circulation, stroke, cognitive function, depression, cancer and other conditions, and find out if it is safe

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