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Protein kinase C inhibitor 7OH-staurosporine (UCN-01) and CDK-family kinase inhibitor flavoperidol down-regulate expression of survival gens and induce apoptosis in B-cell chronic lymphocytic leukemia (B-CLL)
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While these observations are consistent with literature findings, they should be interpreted as indicative rather than conclusive evidence of mechanistic involvement
The latter is considered less efficient and may bring about toxic metabolic byproduct formation
Long-term human safety and efficacy are still being investigated
Purification and crystallization of a schistosomal glutathione S-transferase [PMID: 7675787] Laboratory literature summary: Purification and crystallization of a schistosomal glutathione S-transferase
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