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18 Smoking, biofuel smoke-induced oxidative stress and excessive protease production are major factors in COPD pathogenesis that cause alveolar cell death, destruction of the extracellular matrix in the alveolar region and loss of alveolar structure

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Controlled-release melatonin implants delay puberty in rats without altering melatonin [PMID: 9213263] Laboratory literature summary: Controlled-release melatonin implants delay puberty in rats without altering melatonin rhythmicity

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