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The added complexity and cost make them less suitable for general optimization purposes
The critical role of NAD + pool in tumorigenesis NAD + not only acts as a co-enzyme for metabolic redox reactions, but also functions as a co-substrate to modulate the activity of NAD + -consuming enzymes that govern the critical steps in tumorigenesis, including genome stability, metabolism, cell growth, cell death, redox homeostasis and immune response
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The obtained ADC drug not only retains its in vivo anti-tumor activity, but also improves tolerance and reduces systemic toxicity
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