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Regarding collateral effects, the most commonly reported were gastrointestinal-related (diarrhea, nausea, vomiting, constipation) mainly occurring during the dose escalation period
Actual evidence shows that the negative caloric balance, induced by SGLT2i, can activate AMPK
Ethics declarations Ethics Approval and Consent to Participate Written informed consent was obtained from all individual participants included in the study
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Clinical trials have demonstrated that weight reduction occurs gradually over 12 to 18 months, with most patients reaching maximum effect within this timeframe
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