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Studies suggest growth hormone (GH) and insulin-like growth factor 1 (IGF-1) stimulate collagen synthesis within skin fibroblasts and the connective tissues of tendons and muscles, helping to improve their elasticity and strength (4)

Salama et al

Patients should: Stay well hydrated Eat smaller, more frequent meals Avoid high-fat, greasy, or very spicy foods if experiencing nausea Report persistent or severe symptoms to their prescriber When to seek medical advice: Contact your GP or diabetes team for: Persistent vomiting or diarrhoea Concerns about medication effects or side effects Symptoms of hypoglycaemia if taking other diabetes medications Contact NHS 111 or seek urgent care for: Severe, persistent vomiting preventing fluid intake Signs of dehydration (dark urine, dizziness, reduced urination) Severe or persistent abdominal pain, particularly if radiating to the back (potential pancreatitis) Pain in the right upper abdomen, yellowing of skin/eyes (potential gallbladder issues) Sudden vision changes Allergic reactions (rash, difficulty breathing, facial swelling) Most patients find that side effects diminish significantly after 812 weeks, and the benefits of appetite control and metabolic improvement become more apparent

Vitamin B12 absorption test and oral treatment in 14 children with selective vitamin B12 malabsorption

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I grew up poor in the Bronx, the son of an Italian immigrant family in the 1970s