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New safety signal: dysesthesia (abnormal skin sensations) in up to 21% of participants on the highest dose
While existing systematic reviews and retrospective cohorts have not identified stable, potent teratogenic signals, the heterogeneity in exposure windows, drug types/dosages, and baseline metabolic riskscompounded by residual confoundingrenders any safe vs
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Autophagy 21 , 14731491 (2025)
Current thinking is that GLP-1 agonists increase cAMP in the heart (e.g., Wallner et al
Research suggests that berberine supplementation may be an effective complementary therapy for managing Despite these positive findings, many of the studies were conducted in animals, so further research in humans is necessary to better understand the potential role of berberine in GLP-1 secretion
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