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In the latter conformation, the rAmy bypass motif becomes disordered, enabling the receptor ECD to adopt a position similar to CT-bound CTR or AMYR complexes 15

The mechanism explaining this selectivity is straightforward

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Snchez-Villegas A, Doreste J, Schlatter J, Pla J, Bes-Rastrollo M, Martnez-Gonzlez MA