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The involvement of medicinal chemists will also help delineate the impacts of different structural changes, such as different terminal linkages with GSH ( C -terminal, S -terminal, and N -terminal), on binding selectivity and efficiency, and establish structure-activity relationships (SAR) for the development of glutathione transporter-based brain targeting ligands
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And we think about salt a lot in the case of heart failure because those patients can be very salt-sensitive and a salt load can push them over to requiring hospitalization or medical attention if they take too much
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