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[13] [16] These gastrointestinal effects are dose-dependent and mostly mild-to-moderate in severity

It also pairs naturally with the approach of drinking while medicated to gradually unlearn the reward

SCD is characterized by intravascular hemolysis, driven by the polymerization of mutated hemoglobin within red blood cells (RBCs), leading to vascular inflammation, organ damage, and heme toxicity

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The 6.0 mg dose showed slightly less MASH resolution than 4.8 mg, likely because higher dropout rates from side effects affected the intent-to-treat analysis