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For a deep dive, see Attia #87 with Rick Johnson on fructose

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Side effects are generally experienced when starting treatment and may subside as you get used to the medication

The staged approach may feel unfamiliar or inconvenient, but it's the difference between comfortable eating and spending your evening feeling miserable

a brain-first mechanism means the brain plays a distinct role in how the drug regulates metabolism systemically

If you are not taking creatine and you are curious about the cognitive angle specifically, the evidence is not yet strong enough to recommend it on that basis alone