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Khavinson's theory is that certain short peptides can reprogram gene expression and restore function in aging organs, and Epithalon is the most studied compound in that line of research

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This mechanism may be through the p62-KEAP1-NRF2 pathway to upregulate the expression of multip le genes involved in iron and ROS metabolism (such as SLC7A11, NQO1, HO1 and FTH1), thereby inhibiting cell ferroptosis (Sun et al., 2016b)

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