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The National Institute for Health and Care Excellence (NICE) and British National Formulary (BNF) guidance support a stepwise approach to laxative selection, prioritising agents with favourable safety profiles

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While supply appears to have stabilized as of late, both tirzepatide (Zepbound and Mounjaro) and semaglutide (Ozempic and Wegovy) had been on the FDA shortage list in the past

Amylin has also been associated with weight loss