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They just have not had their bodies tell them yet
The shelterin complex shelters the telomere-loop (t-loop)In face of end-replication problem faced in telomere elongation with progressive cell divisions the components of shelterin complex destabilize and expose the t-loop eventually detected as a DSB, and triggers the DDR
BMRB codes of previously published resonance assignments used in this study are 50398 (human FOXO4 FH domain), 50402 (human FOXO4 CR3), 51125 (human p53 TAD2), 51124 (human p53 194), and 51753 (human p53 DBD)
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