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It is most often studied in combination with semaglutide (a GLP-1 receptor agonist) in a fixed-dose combination known as CagriSema, investigated in the REDEFINE trial programme
Presented for research literature review only Ito Y et al
I've brought this up before on this forum and got all the same kind of advice you got, and I do everything properly, and I've been doing it once or twice a week for years, so for me it's just become a fact of life that it's going to hurt
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But the experience gave me a deep interest in innovative ways to heal the gut, because none of the conventional approaches had worked for me
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