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Key takeaways: First regulatory endorsement linking GLP-1 receptor agonists to MASH treatment Targets adults with non-cirrhotic MASH and moderateadvanced fibrosis Builds on GLP-1 success in obesity and type 2 diabetes Demonstrates histological improvement in liver inflammation and fibrosis Reinforces the role of metabolic pathways in chronic liver disease management This approval signals a shift toward disease-modifying therapies for MASH and highlights how metabolic drugs are reshaping hepatology across Europe
152,153 These cytokines can enter the nervous system from the periphery, with the largest source being autoreactive T cells derived from the atrophied thymus, which strongly contribute to neurodegeneration