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The aim of this review is to summarize the current evidence on the effects of metformin on gut microbial composition and the immune system, as well as its potential role in the treatment of skin diseases
In addition, when used in combination with DOX at sublethal concentrations, a reduction in IC 50 is observed, representing an increase in the net antitumor activity of the drug ( in vitro , P2Et is cytotoxic both in resistant lines with the expression of Pgp + and in Pgp-lines in 2D and 3D cultures ( C
Importantly, ferroptosis has been proven to be a common intervention target for halting DKD progression (187)
doi: 10.1002/biof.1340 63 RathEHallerD
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