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For gut issues, oral capsules work well at 500-1,000mcg daily on an empty stomach

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Malinda et al

While not a substitute for targeted Lyme therapies, it may support immune stabilization during recovery

10.1089/acm.2006.12.881 Summary Keywords vitamin B12, efficacy, bioavailability, therapeutic approaches, meta-analysis, cobalamin Citation Mazur M, Ndokaj A, Salerno C, Vallone J, Ardan R, Bietolini S, Carrouel F, Wilk A, Sarig R, Ottolenghi L and Bourgeois D (2025) Efficacy of sublingual and oral vitamin B12 versus intramuscular administration: insights from a systematic review and meta-analysis

Microarray analysis identified growth hormone receptor among the genes most significantly affected by BPC-157, showing 2.29-fold increased expression