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Elderly individuals, who may have reduced B12 absorption due to age-related digestive changes, can also benefit from B12 injections

This hypoxic concentration is approximately equal to that at Lhasa on the Tibetan Plateau, the highest plateau city [12]

Despite widespread marketing of vitamin B12 pills and injections as weight loss aids, there is no robust clinical evidence to support this claim in individuals who are not deficient

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The first signs of B12 deficiency include persistent fatigue, weakness, lightheadedness, pale skin, tingling or numbness in the hands and feet, difficulty concentrating, and mood changes like irritability or mild depression

Phosphorylation of Akt leads to activation of TOR, a molecular sensor of metabolism and cellular homeostasis (Wullschleger et al., 2006)