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Serious adverse effects require careful monitoring: Pancreatitis : GLP-1 agonists carry warnings about acute pancreatitis risk

Future investigations might focus on their possible impact under varying experimental conditions, including nutrient availability, temporal exposure patterns, and cellular age differences

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About 11% of patients develop prediabetes or diabetes during treatment (likely unmasked by initial labs rather than caused by medication), at which point they become eligible for TRICARE coverage and transition to brand-name medication