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The small sample sizes and high attrition rates (dropping from 51 in month 3 to 24 by month 6 in sample 2) make the results of longitudinal trajectory analyses exploratory as statistical power to detect effects is limited

(PubMed) Davis S, Davis BM, Richens JL, et al

SAYSD1 senses UFMylated ribosome to safeguard co-translational protein translocation at the endoplasmic reticulum

However, the reverse reaction of Michael addition is underutilized

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Clinical evidence suggests that indefinite or very long-term therapy (12+ years) provides the best rebound prevention