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JAMA Netw Open 7(6):e2416775 Mabilleau G, Mieczkowska A, Chappard D (2014) Use of glucagon-like peptide-1 receptor agonists and bone fractures: a meta-analysis of randomized clinical trials

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Evidence indicates that a meaningful proportion of weight reduction (~25-40%) may involve lean tissue, including skeletal muscle, particularly in the absence of adequate nutritional intake or strength training

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In preclinical rodent research it is characterized as a cytoprotective and angiomodulatory agent, reported to influence the VEGFnitric-oxide signaling axis, modulate angiogenesis during muscle and tendon healing, and promote granulation-tissue and collagen formation at wound sites