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When to seek help Contact your clinic or a doctor if you have severe or escalating pain, swelling that worsens after several days rather than improving, signs of infection (pus, spreading redness, fever), unusual skin discolouration, or lumps that persist beyond three to four weeks
Schedule: First injection timed so that days 2 and 3 fall on low-obligation days
2.1.4 BBB disruption METH compromises BBB integrity, allowing peripheral immune cells to infiltrate the CNS (Ramirez et al., 2009)