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The phase 2 trial published in The New England Journal of Medicine in 2023 enrolled adults with obesity without type 2 diabetes and demonstrated dose-dependent weight loss of up to 24.2% of body weight at the highest dose over 48 weeks results that attracted considerable scientific and media attention
Others have demonstrated that the positive outcomes of obesity surgery (i.e., changes in body weight and improved glucose homeostasis) are sustained in mice in the absence of GLP-1R or Y2-R, or both GLP-1R and Y2-R 66,67
Hepatology 72 , 5871 (2020)
Sun, Lena H
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A 5mL vial at 10mg/mL contains 50mg, enough for 20 weeks at 2.5mg
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