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Microbial metabolites such as SCFAs and tryptophan catabolites can influence brain function directly or via modulation of systemic inflammation

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A systematic review of 18 studies highlighted the critical role of aging, inflammation, and shifts in gut microbiota, particularly involving Firmicutes, Bacteroidetes, SCFAs, and TMAO, in the pathogenesis and outcomes of ischemic stroke

Integrative models of structural and matrixlinked signaling. Annu Rev Physiol

10.3389/fneur.2021.689069 36 KhatoonS.SamimM.DahaliaM.NidhiN