In addition to their direct inflammatory effects, neutrophils further orchestrate inflammation and tissue remodeling by actively engaging in crosstalk with other cells within the immune microenvironment, such as endothelial cells, monocytes, platelets, and T and B cells
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Adipose tissue plays an active role in oestrogen production and metabolism, and rapid weight loss can disrupt the hypothalamic-pituitary-ovarian axis
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LPS, a glycolipid, does not directly influence BV-2 microglial cell activity (consistent with our observation