Sssmuth and Mainz, 2017
Expression of the glutamine transporter Slc1a5 is regulated by MYC and is elevated in MYCdriven liver tumors 11, 12
TdGSH erased LOsG-induced cell metabolic memory (MM) in ROS homeostasis Glucose/ROS pathways promote cellular adaptive processes, which can alleviate glucose-dependent ROS stress-induced detrimental effects on cell survival and subsequently allows for the development of MM 18 , which exists in diabetic patients
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The X-box-binding protein-1 (XBP1), spliced and activated by IRE1, is downregulated in glomerular mesangial cells, weakening the inhibitory effect on the phosphatase and tensin homolog (PTEN)/Akt pathway, thereby aggravating kidney damage