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In the present study, supplementation of withanolide A reversed hypoxia induced down regulation of Nrf2 in the hippocampal region of the brain with concomitant increased expression of GCLC
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The two-faced effects of reactive oxygen species and the lipid peroxidation product 4-hydroxynonenal in the hallmarks of cancer
But it is important to consider that though intravenous injections increase the bioavailability and increase the efficacy of glutathione, they can also pose the risk of overdosing and toxicity
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Glutathione can also cause changes to gene expression, DNA and protein synthesis, cell division and growth, and programmed cell death (apoptosis)
