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We propose that trimetazidine is a promising drug that can be repurposed to target mitochondrial dysfunction, inflammation and oxidative stress to treat bipolar depression

Fibroblast Growth Factor 21 Analogs: Clinical Experience in Patients with Metabolic Disease In humans, FGF21 analogs have recapitulated many of the lipid effects and some of the glycemic effects observed in preclinical species, though notably not with all compounds tested ( Figure 3B )

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Annexin V binds phosphatidylserines that translocate to the outer leaflet of the membrane during early apoptosis 61 , whereas 7-AAD is a membrane-impermeable DNA dye that labels cells with compromised membrane integrity, identifying cells undergoing lytic forms of cell death such as necrosis, secondary necrosis and pyroptosis 62,63