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MinJWuLLiuYSongGDengQJinWet alEmpagliflozin attenuates trastuzumab-induced cardiotoxicity through suppression of DNA damage and ferroptosis
The Risk: Both drugs can cause this if dosed too aggressively
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The primary mechanism by which they suppress ferroptosis, specifically on the inner mitochondrial membrane, involves the reduction of CoQ10 to its antioxidant form, CoQ10H2 (Mao et al., 2021)
Neurogastroenterol Motil 2009
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